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Disease Fighting Gene Therapies Developed That Fight Many Illnesses

By Morgan Carroll


Gene therapies have been developed that transform gene expression. The therapies use molecular cell science, stem cell and recombinant DNA to treat various diseases by manipulating genes.

Inborn errors of metabolic process or hereditary defects are reversed or repaired by gene therapies that place a functioning gene into the cells of the affected individual to correct cell dysfunction.

Genetic code generates the instructions to treat a disease or disorder by placing the code into cells and creating a repaired function or restoring a missing function. Worldwide, there are thousands of medical clinical trials underway.

Numerous genetic disorders are caused by different genes working together: Diseases such as diabetes, hypertension, Parkinson's disease, heart disease, autism, Alzheimer's disease, ADD ADHD, peptic ulcers, pain and cancer.

Gene treatments are most successful when used theraputically against diseases caused by one gene. There are more than 6,000 known gene disorders caused by a sole gene.

Genetic researchers are currently exploring ways to safely treat a variety of diseases:

Amoung them are hypertension, ocular diseases, malignant glioma, ovarian cancer, Huntington's corea, renal cancer glioblastoma multiforme, metastatic melanoma, ocular diseases and hereditary immune deficiencies.

And Huntington's disease, bubble boy disease (SCID), HIV-AIDS, muscular dystrophy, diabetes, heart disease, cystic fibrosis, Huntington's disease, blindness and hemophilia.

Unregulated cell growth is the hallmark of cancer. It's not a single disease. The impairing of normal physiological functions and the spread of the cancer to other parts of the body are the targets of cancer gene therapies.

Various types of gene therapy have been developed by researchers to treat or protect against different types of cancer.

Cancer occurs because mutations in a cell that causes it to multiply out of control. Cancer gene therapies, to control unimpaired cell multiplication, make up about two-thirds of continuing gene therapy clinical trials.

The human body generates tumor suppressors that inhibit cancer. For example, P53 is a tumor suppressor when mutated causes about half of all cancers, and the BRCA1 and BRCA2 genes are also suppressors, but when mutated may indicate the occurrence of breast and ovarian cancer.

Prostrate cancer is the most frequently diagnosed cancer in men, and the second foremost cause of death in American males. The herpes simplex virus gene, used in prostrate cancer gene therapy, has been effective in transferring curative DNA.

With head and neck cancers, impairment of the 9p21 gene is the hallmark genetic error. The gene is also implicated in cardiovascular disease and diabetes. It happens early in the progression to cancer. An impaired or mutated P53 tumor suppressor gene occurs in 1/2 of all cancers.

Diseases will be ultimately be treated by the merger of gene therapy and stem cell therapy. Stem cells can be triggered to turn into any of the body's numerous cell groups.

Gene therapy is a quickly developing type of genetic molecular treatment with the potential to deliver new cures for inherited and acquired life-threatening diseases.

It 's in accordance with the concept of inserting a gene into a person's genome, in either the complete body or in distinct parts, to alter the gene expression of that cell or group of cells, and to make use of this technology to help remedy disease.




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